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NADPH oxidase is a pro-oxidant enzyme (Erlich et al., 2022) that facilitates the transfer of electrons from NADPH to oxygen, generating O2 and other downstream ROS (Bedard and Krause, 2007)

ChenALanZLiLXieLLiuXYangXet alSodium-glucose cotransporter 2 inhibitor canagliflozin alleviates vascular calcification through suppression of nucleotide-binding domain, leucine-rich-containing family, pyrin domain-containing-3 inflammasome

Detoxification : It helps in the detoxification of harmful substances, including heavy metals and toxins, making it crucial for liver health

The energy released during this process is harnessed to transport protons across the IMM, generating a proton motive force that drives oxidative phosphorylation (OXPHOS), culminating in ATP production by ATP synthase [58, 59]

62 A strong release of cytokines has been proposed to be associated with lung injury and dysfunction of multiple organs (Fig