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2017;4:30323.e1

Response: We appreciate and acknowledge commenters' concerns regarding the CPT coding

This work was further supported by MHRUK and Angharad-Dodds Bursaries to M.B

Epidemiologic evidence suggests that gut flora disruption due to antibiotic use early in life is associated with an increased risk of developing IBD (258), particularly in the first year of life, as antibiotic use may cause intense and prolonged microbial disruption at a critical time and have long-term effects on the immune system, increasing its risk of future IBD