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This activates the intrinsic pathway via mitochondrial outer membrane permeabilization, releasing cytochrome C and forming the apoptosome complex with apoptotic protease activating factor-1 (Apaf-1) and procaspase-9 (Hashemi et al

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Oxidative deoxyribonucleic acid damage in the eyes of glaucoma patients

ArticlePubMedPMC 56

The reality and challenge of the present situation is that there is no specific drug to treat and cure the disease

By inhibiting HIF-1s transcriptional activity, FDA-approved proteasome inhibitors like Bortezomib can block the accumulation of proteins like CAIX, EPO, and VEGF (158)