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elegans : Caenorhabditis elegans CEPs: Cephalic sensilla neurons DAT: Dopamine transporter DHE: Dihydroethidium DOPAC: 3,4-Dihydroxyphenylacetate acid DOPAL: 3,4-Dihydroxyphenylacetaldehyde PD: Parkinsons disease ROS: Reactive oxygen species GABA: Y-aminobutyric acid GFP: Green fluorescent protein ILS: Insulin-like signaling KRS: Kufor Rakeb syndrome L-DOPA: L-3,4-dihydroxyphenylalanine MAO-B: Monoamine oxidase B MDA: Malondialdehyde mitoUPR: Mitochondrial unfolded protein response MPP + : 1-Methyl-4-phenylpyridinium MPTP: 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine PDEs: Posterior deirid neurons SN: Substantia nigra TH: Tyrosine hydroxylase VMAT2: Vesicular monoamine transporter References Akinyemi AJ, Miah MR, Ijomone OM, Tsatsakis A, Soares FAA, Tinkov AA et al (2019) Lead (Pb) exposure induces dopaminergic neurotoxicity in Caenorhabditis elegans : involvement of the dopamine transporter

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Among the other neuroprotective mechanisms that have been proposed are an antioxidant effect (Chiueh et al, 1994) and the preservation of mitochondrial membrane potential, and an associated inhibition of mitochondrial permeability-transition pore opening (see Wadia et al, 1998