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Zafar et al., 2024a)

Tsvetkov P and his team compared mice lacking the ATP7B gene (a mouse model for Wilsons disease) with normal mice, and observed typical indicators of cuproptosis in liver cells of mice lacking the ATP7B gene, including lipoylated protein oligomerization, depletion of iron-sulfur proteins, and increased abundance of HSP70 ( Both ATP7A and ATP7B are highly relevant to diabetes

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In contrast, the IC 50 value at which Mito 10 -NAC directly inhibits complex I-induced oxygen consumption is 37 M

Only those probe-modified peptides that were evident across two out of three biological replicates were interpreted for their isotopic light to heavy ratios