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3.2 Risk factors 3.2.1 Genetic factors Past genetic studies have shown that congenital and early-onset hearing loss has a genetic component, which appears to be a characteristic of ARHL (Azaiez et al., 2018)

Biological aging is the result of cellular decline now understood to be due to a combination of oxidative stress and telomere shortening

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Nitrotyrosine is considered a biomarker for oxidative stress as the result of the nitration of protein-bound and free tyrosine residues by reactive peroxy nitrate molecules formed when nitric oxide reacts with superoxide [8]

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