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A previous study by Kang et al

elegans , in response to microbial infection, produces several reactive oxygen species (ROS) 67,68

94 The hypoxic microenvironment reduces osteogenic efficacy during bone regeneration, not only by directly reducing cellular activity but also by promoting the accumulation of pro-inflammatory mediators such as reactive oxygen species (ROS)

Conclusion The sudden outbreak of SARS-CoV2 infection is currently associated with an ongoing progress in the knowledge of underlying pathogenic mechanisms, which is highlighting the immunophenotypic traits which characterize the infected patients more susceptible to the development of heavy lung damage caused by cytokine storm

Vitamin E reduces the negative effect of corticosterone, vitamin C is vital for various biosynthesis(collagen, 1,25 dihydroxy vitamin D and adrenaline) and regulation of diverse reaction(secretion of corticosterone, regulation of body temperature and activation of the immune system)