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By assigning metabolites to the signals shown in the loading plot (Figs 4B and S5B) and quantifying the variation observed for each metabolite among the different classes, we found that overall, vB12 treatment induced significant metabolic changes in Tbx1 +/ mice only (Figs 4A, S5A, and S6, Table S1, Group 3)

In a recent paper, we used their basic method but with GHK : Cu(2+) and ascorbic acid, which strongly suppressed sarcoma 180 in mice without any evident distress to the animals [7]

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This pharmaceutical design principle appears in several modern peptide therapeutics