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Neuroimaging and histological studies have provided evidence of significant iron accumulation in affected regions in both patients and animal models, suggesting a role for ferroptosis in the distinctive pattern of motor neuron loss in ALS

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doi: 10.1210/jc.2010-2986 56 HoffGBernklevTJohnsenLReitsmaLSinaDLauzikeAet al

United Kingdom Prospective Diabetes Study 24 (1998): A 6-year, randomized, controlled trial comparing sulfonylurea, insulin, and metformin therapy in patients with newly diagnosed type 2 diabetes that could not be controlled with diet therapy