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Ghrelin (Growth hormone release inducing)

It is worth to mention that available reports describing the encapsulation of GSH- or albumin-protected AuNCs are limited to hydrophilic, rather than hydrophobic, matrices such as nanogels 25 , aqueous core of microcapsules 26 , silica nanoparticles, protein nanoparticles 27,28 , polymer nanoparticles 29,30 and metal-organic frameworks 31

Further, 4-hyroxynonenal (HNE), a major lipid peroxidation product, induces Nrf2 signalling and the expression of GSH-synthesizing enzymes, thereby increasing the level of GSH in the cells [29]

[Qn 4] Who can benefit from this treatment

The activity of caspase 3, but not caspases 1, 8, or 9, is increased in the BSO-treated E47 cells, and damage to mitochondria appears to play a role in the CYP2E1- and BSO-dependent toxicity, because mitochondrial membrane potential is found to be decreased in the process [124]