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Thus, we tested here whether increased VEGFA expression specifically in the RPE (and not in the retina or circulation) is sufficient to induce RPE barrier breakdown and neovascular AMDlike pathologies, by generating mice that overexpress VEGFA only in the RPE postnatally (Vmd2Cre +/WT /ROSASTOP fl/fl VEGFA 164 mice)

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Jan 18 2023;24(3)doi:10.3390/ijms24031866