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Both groups exhibited significant Breg reduction at day 1 post-immunization

Nat Rev Mol Cell Biol 25:701719

25 mg per day appears to be the most common MK-677 dose used in past research

Whitfield ML, Finlay DR, Murray JI, Troyanskaya OG, Chi JT, Pergamenschikov A, McCalmont TH, Brown PO, Botstein D, Connolly MK (2003) Systemic and cell type-specific gene expression patterns in scleroderma skin