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It is thought that these mutations may minimize the FcR-mediated, HER2-independent uptake of ADC by normal tissues, thereby reducing off-target toxicity [63]

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Avoiding Air Bubbles: Any air bubble in the syringe will have negligible effect on an insulin dose (because insulin is a suspension), but aim to remove large bubbles when drawing insulin

25,26 These mutations lead to BMPR2 protein truncation and nonsense-mediated messenger RNA (mRNA) decay, resulting in disrupted BMPR2 signaling

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