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This reflects how the compounds are studied, not a dosing recommendation

Adverse effects: Seek medical advice if you develop any unusual, severe, or persistent side effects or symptoms after taking vitamin B12 supplements

Patients are often advised to fast for several hours before the test, as recent food intake can affect folate measurements

however these compounds are labelled as research compounds and not for human use, and aren't vetted by the FDA

As the commenters noted, for the 2023 performance year, this resulted in some Shared Savings Program ACOs effectively not being scored on the MCC measure and having greater weight placed on the remaining measures in the APP quality measure set because when the denominator for a quality measure is reduced to zero, the measure is removed from the performance category score