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SSc has a worldwide distribution, with an average onset age between 30 and 50, and a higher prevalence in females than males [236]

Dickinson DA, Levonen AL, Moellering DR, Arnold EK, Zhang H, Darley-Usmar VM et al

Consequently, through the lens of ferrology, targeted modulation of iron balance and ferroptosis has emerged as a compelling avenue for the prevention and treatment of major diseases