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Finally, we can conclude that the redox environment is an essential variable to the entire system: maintaining a good immune response [31] and suitable neurogenic events [32], controlling growth, behavior, propagation, and differentiation of tumor cells [33], and most of all ensuring the correct function of organelles like the endoplasmic reticulum [34]

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This adaptive program is referred to as the integrated stress response (ISR) and is initiated by stress-activated protein kinases, including general control nonderepressible 2 (GCN2) activated upon amino acid deprivation and protein kinase RNA-like endoplasmic reticulum kinase (PERK) activated by ER stress, among others, which phosphorylate eIF2 on Ser51 (Harding et al., 2000)

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Heres what happens during a cold flash: Fluctuations of estrogen disrupt the hypothalamus, the thermoregulation center of the brain