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Initial reports that a gain-of-function polymorphism (L503F variant, rs1050152) in SLC22A4 that increased transport efficiency of ergothioneine was associated with increased risk of Crohns disease (Reference Peltekova, Wintle and Rubin56) were subsequently shown to have been confounded by the SLC22A4 gene being in linkage disequilibrium with the interferon regulatory factor 1 ( IRF1 ) gene, which was the locus conferring Crohns disease susceptibility (Reference Huff, Witherspoon and Zhang57)

To date, 5 homogenous bioactive polysaccharides or proteoglycans have been purified from Huaier, including TPG-1, HP-1, W-NTRP, TP-1, and SP1

For Tb.Sp, the SF/HAMA/DDM-50 group had the lowest Tb.Sp, indicating that the new bone in this group has the highest bone density

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J.SessaW