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Mechanism of -Pro/C-degron recognition by the CRL2 FEM1B ubiquitin ligase

These observations underscore the involvement of the hypoxic microenvironment in MS-associated vascular pathology, implying that strategies aimed at improving vascular oxygenation, mitigating immunoinflammatory damage, downregulating vasoactive substances, and reversing vascular abnormalities may reduce ischemic damage to the skin and visceral organs

Profiles Dr Tim Jackson Consultant in Palliative Medicine Northern Care Alliance NHS Trust Dr Tim Jackson has been a consultant at Salford Royal Hospital and St

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Lastly, it is important to remark that ED could represent an early predictor of CV events and the diagnosis of vasculogenic ED at PDU, and particularly at dynamic PDU as the gold standard diagnostic tool, both in patients with or without additional CV risk factors and/or comorbidities, can help to recognize eventual arterial diseases in biggest distal vessels [35, 39,40,41]