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Other evidence shows in a murine breast cancer model (4T1) that following phagocytosis of cellular debris from tumor cells treated with chemotherapy (paclitaxel) TAMs upregulate the expression of HO-1, which in turn hinders M1 polarization and attenuates the response to chemotherapy

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Of note, CpG and CL097 but not poly:IC stimulated IL-6 secretion in this assay, while poly:IC was the most efficient stimulus in inducing IFN secretion by CD11c + DCs (Fig

Yang Y, Sheng L, Hang X, Wang J, Kou G, Ye Y, Ji J, Sun X (2025) Efficient expression and activity optimization of manganese peroxidase for the simultaneous degradation of aflatoxins AFB(1), AFB(2), AFG(1), and AFG(2)

Several reports have proposed that ERG behaves as an antioxidant, scavenging hydroxyl radicals to prevent DNA damage and lipid peroxide formation 18,19,20