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Name: l carnitine tmao reddit JCI The Basics of Metabolic Dysfunction–Associated
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The Basics of Metabolic DysfunctionAssociated Steatotic Liver Disease for Cardiologists: Pathophysiology, Diagnosis, and Treatment JACC Heart failure and trimethylamine Noxide: time to transform a 'gut feeling' in a fact? Crisci 2023 ESC Heart Failure Wiley Online Library Full article: The bright and the dark sides of L carnitine supplementation: a systematic review Revisiting the Role of Carnitine in Heart Disease Through the Lens of the Gut Microbiota PMC Intestinal microbiota metabolism of l carnitine, a nutrient in red meat, promotes atherosclerosis Nature Medicine

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doi: 10.1038/nchembio.1352

In addition to AGEs and AGE adducts, HMGB1 and A can bind RAGEs to activate the NF-B, ERK1/2, p38, JNK, PI3K, Janus kinase/signal transducers and activators of transcription (JAK/STAT) pathways, leading to neuronal cell death and neurodegeneration 112