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PubMed Central , Experimental Eye Research , vol

Methylcobalamin is an active coenzyme form, but clinical evidence does not demonstrate superior efficacy over cyanocobalamin for most people

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The water-soluble nature of B12 means several things for patients : the vitamin requires regular dietary intake to maintain optimal levels, it can be lost during food preparation (particularly with prolonged cooking or boiling), and therapeutic doses are generally considered safe as excess is eliminated through the kidneys, though the body's substantial hepatic storage also plays a role in B12 metabolism