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Biomed Res Int 2013:241721

[28] demonstrated that recombinant human IGF-1 (rhIGF-1) increased the expression of FoxP3 factor and in vitro stimulated the proliferation of murine Tregs but not that of other T-cell subtypes

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In addition to the GLStargeted compounds, inhibitors that target the conversion of glutamate to KG have also been tested in preclinical models of breast cancer and neuroblastoma (Qing et al , 2012