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4 The role of the Wnt/-Catenin signaling pathway in the tumorigenesis and progression of HCC 4.1 Wnt/-Catenin signaling pathway and HCC tumorigenesis Aberrant activation of the Wnt/-catenin signaling pathway is one of the main driving factors in the tumorigenesis of HCC and is widely present in HCC patients, with their relationship being well established

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*Correspondence: Ke-Vin Chang, [email protected] This article was submitted to Drugs Outcomes Research and Policies, a section of the journal Frontiers in Pharmacology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers