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Although analyzing DNA methylation in blood as a surrogate for brain has its limitations with regard to underrepresentation of the alterations that take place in the disease-affected tissue, it has a potential use in the identification of biomarkers that could help diagnosis and disease monitoring

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Other possible host cells may be in a metabolic activated state that is, however, adverse for the proliferation of most IBPs (e.g., classically activated M1-MPs, activated plasmacytoid dendritic cells, pDCs, and neutrophils)