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Therefore, considering significance of both NO-system and egr-1 gene-systems for inflammatory bowel disease (54) as well as for multiple sclerosis (55-57), these may be important also when confronted with severe complications of advanced and poorly controlled IBD as well as multiple sclerosis

doi: 10.1038/s41419-018-0468-2 48 ChenS.SayanaP.ZhangX.LeW

Epilepsy Single case reports describe decreased seizure frequency, but larger studies have not documented any benefit