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265,266 PERK-eIF2-ATF4 signaling in angiogenesis, EMT, and metastatic progression Persistent activation of the cytoprotective arm of the UPR can actively drive tumorigenesis and malignant progression

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The tolerability story is also good: nausea rates of 25% are lower than Semaglutides, which aligns with the theory that GIP co-activation improves GI tolerance

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For instance, the cost of LAIs (particularly newer, second-generation LAIs) has been cited by physicians as a reason for not prescribing these treatments [3]