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Additionally, we showed that etoposide , a topoisomerase II inhibitor that restrains DNA replication, effectively inhibits proliferation of NKX21 overexpressing cells

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10.1016/J.JCF.2017.09.001 231 RossiE.FalconeM.MolinS.JohansenH

This prompted testing of vertical dual inhibition of MAPK pathway with BRAF and MEK inhibitors, an approach that has improved response rates in melanoma