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lipolytica can utilize hydrophobic substrates (e.g., oleic acid) for growth, ex novo lipid synthesis, and bioproduct synthesis (e.g., citric acid), hence its species nomenclature (Madzak, 2021)

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However, their efficacy is linked to the need of a minimum intake of caffeine of 3 mg/kg (Jimnez et al., 2021), considered the optimal dose for the ergogenic effects (Guest et al., 2021)