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The decline in age-related melatonin production is attributed to different reasons

Isenovic, [email protected] This article was submitted to Cellular Endocrinology, a section of the journal Frontiers in Endocrinology Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Finally, after validating their pro-oligodendrogenic activity in vitro and ex vivo, we selected the top two compounds, leucovorin and dyclonine, and demonstrated their capacity to promote oligodendrogenesis and myelin repair in vivo, using both neonatal and adult murine models of myelin pathologies

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