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The authors reported that AOD-9604 stimulated lipolysis in isolated adipocytes and that chronic daily treatment in obese Zucker rats produced reductions in body weight gain of more than 50% relative to untreated controls over the treatment period, without effects on insulin sensitivity or IGF-1 levels [3]

Subsequent work from the group of Jun Lui in 2010 identified G0S2 as a bona-fide binding partner of PNPLA2, capable of inhibiting its TAG hydrolase activity (52) (Figure 1)

Administered as a synthetic peptide, tesamorelins primary action site is the pituitary gland, nestled at the brains base