is 5 amino 1mq liver toxic Selective and membrane-permeable small molecule inhibitors of nicotinamide N-methyltransferase reverse high fat diet-induced obesity in mice 5-Amino-1MQ UK | Research Grade

And its one where the chemistry gives a clearer answer than most compounds in this space

This early response may reflect the body's immediate utilisation of available B12 for urgent metabolic processes

It is a coenzyme your cells already make from vitamin B3, and it is central to two things: shuttling electrons through energy metabolism, and serving as a required cofactor for sirtuins, PARPs, and CD38

Prevents fatty liver disease Enhances detoxification Improves cholesterol metabolism Supports bile production Who Benefits Most from MIC+B12

Research has not shown that doses above 0.5 mg per day provide meaningfully better results, so there is no benefit to pushing higher