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The FDA label for Increlex explicitly warns of hypoglycaemia, intracranial hypertension, and slipped capital femoral epiphysis as serious adverse events

This is an interesting point when you consider that in prostate cancer it has been shown that estrogen can substitute to upregulate IGF-1R when androgen levels are low (Turcu et al., 2017)

(xliv) a luteinizing hormone releasing hormone (LHRH), a LHRH analog or derivative, a luteinizing hormone agonists or antagonists including, but not limited to, letrozole, anastrazole, atamestane, fadrozole, minamestane, exemestane, plomestane, liarozole, NKS-01, vorozole, YM-511, finrozole, 4-hydroxyandrostenedione, aminogluethimide, or rogletimide

The elevation is dose-dependent up to a saturation point, which research places at approximately 1 mcg per kilogram of body weight per injection

Molecular Mechanisms Underlying the Link between Diet and DNA Methylation