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Immunofluorescence Cells grown on coverslips were fixed with cold methanol at 20 C and then incubated with the following primary antibodies: anti-LC3A/B rabbit monoclonal (1:100) (Cell Signaling Technology, Inc., New England Biolabs., UK), anti-Phospho-S6 Ribosomal Protein rabbit monoclonal (1:100) (Cell Signaling Technology), anti p53 mouse monoclonal (1:100) (Dako Cytomation, Glostrup, Denmark) and anti-Ki67 rabbit polyclonal (1:300) (Abcam, Cambridge Science Park, Cambridge, UK)

Two adjacent subunits are connected to each other by the exchange of C-terminal regions containing helices 12 and 13

Cancer Epidemiol Biomarkers Prev 3:310 Qiao X, Li G, Zhang J et al (2022) Urinary analysis reveals high Alternaria mycotoxins exposure in the general population from Beijing, China

518 This was observed through improved glycemic control, reduced occurrence of liver cancer, and better liver histology compared to the control group

Given its essential role in the detoxification of lipid hydroperoxides, and its overexpression in most of myeloid malignancies, GPX4 inhibition has emerged as a promising therapeutic strategy to specifically trigger ferroptosis and eradicate myeloid leukemia cells