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Rapid weight loss combined with reduced food intake can accelerate bone loss in some patients, particularly postmenopausal women

A meta-analysis was conducted by combining the results from the two cohorts

OS also reduces tetrahydrobiopterin (BH4), a critical cofactor for eNOS, causing it to produce more ROS instead of NO, thereby amplifying endothelial injury (Hernandez-Navarro et al., 2024)

Nucleic Acids Res 48(16):91099123 Paupe V, Dassa EP, Goncalves S, Auchre F, Lnn M, Holmgren A et al (2009) Impaired nuclear Nrf2 translocation undermines the oxidative stress response in Friedreich ataxia

PubMed record Spth-Schwalbe E, Schfer A, Uthgenannt D, Born J, Fehm HL