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10 WitherspoonJGHallJRJimaDAtkinsHMWamsleyNTMajorMBet al

Textbook of Medical Physiology (11th ed.)

Morbidity and Mortality Weekly Report, 31(22), 290-291

However, the considerable overlap of functions between these receptors is exemplified in breast cancer where it has been suggested that inhibition of both IGF-1R and IR may be required for effective antitumour response ( As well as the hypothalamic pituitary GH axis, IGF-1 secretion is controlled by autocrine/paracrine signals in peripheral tissues