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However, in contrast to simple obesity, where GH is low and IGF-I within normal range (89), subjects with MASLD demonstrate variable changes in the GH/IGF-I axis depending on disease severity (121123) ( Table 1 )

Targeting the PTEN-induced signaling pathway Based on the function of PTEN in inhibiting the PI3K/Akt signaling pathway and inducing apoptotic cell death via excitotoxicity, regulating PTEN could possibly help ameliorate excitotoxicity and, in turn, neurological deficits in ischemic stroke

10.1523/JNEUROSCI.1157-07.2007 187 WangH