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Alterations of purinergic receptors levels and their involvement in the glial cell morphology in a pre-clinical model of autism spectrum disorders

Neuropsychol Rev 2008

It has been suggested that when LPS binds to TLR4, it stimulates the expression of TNF-, IL-12, and IFN- through the bridging protein-myeloid differentiation factor 88 and NFB signaling pathways, thereby stimulating the differentiation of T cells to Th1 and Th17.LPS also stimulates the release of IL-6 and TNF- from B cells, as well as increasing their antibody production (Zhou et al., 2014)