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A strategic approach to treating GBM involves exploiting the nuances of DNA repair mechanisms to create a situation where the repair capacity is overwhelmed by the rate of damage, thereby enhancing the efficacy of therapies [158]

DCs are a type of cell of special origin that can be derived from both lymphoid stem cells and myeloid stem cells

YAP enhances TCA activity by increasing Lars2 expression, whereas ARID1A deletion forces metabolic flux toward the TCA cycle by suppressing PKM

Sustained microglial activation leads to the release of pro-inflammatory cytokines such as TNF-, IL-1, and IL-6, which exacerbate neuronal injury and amplify amyloid and tau pathology (Kaur et al., 2019)

Nicolescu, A., Babot, M., Barros, L., Rocchetti, G., Lucini, L., Tanase, C., Mocan, A., Bunea, C