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6.2.3.3 Cytokine dysregulation and myelin swelling Elevated levels of proinflammatory cytokines, such as TNF-, and reduced levels of epidermal growth factor have been observed in Vit B12-deficient states (Scalabrino et al., 2000)

[DOI] [PubMed] [Google Scholar] 32.Ilic S, Drmic D, Zarkovic K, Kolenc D, Coric M, Brcic L, et al

doi:10.1080/1028415x.2019.1620425 Hardman RJ, Meyer D, Kennedy G, Macpherson H, Scholey AB, Pipingas A

99,100 In a controlled trial that enrolled 62 men, 4 grams myo-inositol plus 400 mcg (680 mcg DFE) folic acid daily for two months increased sperm concentration and motility in those with sperm abnormalities and infertility as well as those with normal sperm and fertility

Research is still ongoing, so more developments are to be expected in the future