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Clria, 2 , the most abundant PG, has been previously reported to mediate several biological phenomena, such as homeostasis (Sugimoto et al., 2000), inflammation, pain (Davies et al., 2010)

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For standard oral supplements, competition with other nutrients and the activation of digestive enzymes can hinder absorption

However, these adaptive endocrine changes, when prolonged, are associated with a reduced metabolic rate and impaired growth in severely malnourished children [38,39,40] Recent studies report significantly lower free T3, free T4, TSH and serum albumin levels in SAM as compared to moderate acute malnutrition (MAM), with strong, positive correlations between albumin and thyroid hormones [32, 34, 41] Nonetheless, findings on TSH remain inconsistent, as some studies showed no differences between SAM and MAM [32, 33, 36] while others reported significantly higher [42] or lower [41, 43] levels in SAM