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Curcumin loaded exosomes (Exo-CUR) was administered orally to nude mice containing the cervical Ca Ski-tumor xenograft to assess its in vivo anti-cancer efficacy

This emanates from the fact that synthetic drugs are designed for just a purpose (for instance, treatment of a particular disease) and targeting a certain pathway and mechanism, while a large number of studies have revealed that naturally-occuring compounds are capable of affecting a wide variety of molecular signaling pathways (Guo et al., 2019

Histamine also upregulates NE

By contrast, despite promoting increased ROS production, human cytomegalovirus (HCMV) infection positively modulates Nrf2 expression

Qu J, Liu Q, You G, Ye L, Jin Y, Kong L, Guo W, Xu Q, Sun Y