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In human cells, both the cytoplasm and the mitochondria have their specific ARSs

Gut Liver 15 , 827840 (2021)

10.1016/j.biochi.2014.08.018 37 HeC.WuY.LaiY.CaiZ.LiuY.LaiL

In practice, these interdependent parameters are tuned in combination to achieve the desired in vivo behavior and provide the physical and pharmacokinetic scaffold on which more specialized functional units can be built

Under conditions of oxidative stress, the mitochondrial electron transport chain becomes less efficient, leading to increased production of superoxide radicals [86]