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The most common adverse reactions (incidence 20%) of pemetrexed, when administered in combination with cisplatin are vomiting, neutropenia, anemia, stomatitis/pharyngitis, thrombocytopenia, and constipation

because we don't absorb all the B12 that we ingest

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The panelists agreed that symptoms related to the peripheral and central nervous systems are the most common symptoms in patients with clinically manifested vitamin B12 deficiency (Figure S3)