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while there are promising results seen in trials and retrospective data analysis, its excellence as a first-line therapy may supersede benefits seen in transplant conditioning

PMID: 2555512 PMC1572913 Pigmentation Pathway (MC1R, Preclinical) Eumelanin upregulation via cAMP / MITF / tyrosinase axis MC1R activation by melanocortin agonists is reported to raise intracellular cAMP, upregulate MITF, and increase tyrosinase-mediated eumelanin synthesis in epidermal melanocyte models

Damage to the retinal microvessels is secondary to the local pressure increase, atherosclerosis and inflammation [47]

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The injections are administered directly into the skin and can help to reduce the appearance of dark spots, pigmentation, and uneven skin tone