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Another study published in Growth Hormone and IGF Research showed that single CJC-1295 administration elevated GH and IGF-1 in healthy young men and altered serum protein profiles linked to GH/IGF-1 action, suggesting biological activity relevant to protein turnover and tissue repair

Because of this effect on MAO-A, the use of intravenous methylene blue has been associated with the development of serotonin syndrome 1-8

It upregulates matrix metalloproteinases (MMPs), which are enzymes that break down old, damaged collagen and extracellular matrix components

For context, the Phase 2 study (Jastreboff 2023, NEJM) reported about 17.5 percent mean weight reduction at 24 weeks on 12 mg

Reported Adverse Effects Reported adverse effects from online forums cited in a 2025 systematic review (PMC12313605) included: Anxiety and panic attacks Depression and anhedonia Insomnia Heart palpitations Fatigue and weakness Loss of appetite These anecdotal reports cannot be verified as directly caused by BPC-157 versus contamination, incorrect dosing, or concurrent conditions, but they raise concerns that the peptide might paradoxically worsen mental health in some individuals