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In order to decrease the amount of tau phosphorylation and the formation of neurofibrillary tangles, siRNA against microtubule-associated protein tau (MAPT) has been shown to have a protective effect on synapse function and neuronal survival (101)

And thats a little different than the free radicals that are produced during normal aerobic activity

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In the BMP pathway, ACVRL1 and ENG are receptors involved in the phosphorylation of SMAD1 and are expressed in the mature lung vasculature