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In: RizwanA, editor

GPx4 lacks a loop structure in the active site of the enzyme, as compared with GPx1-3

ME2 may be involved in glutaminolysis, and the ME2 reaction produces mitochondrial pyruvate, which is then converted to acetyl-CoA, which is then used to generate additional ATP via the TCA cycle and electron transport chain-mediated oxidative phosphorylation (Fig

Bai J, Wang Y, Zhu X, Shi J (2019) Eriodictyol inhibits high glucose-induced extracellular matrix accumulation, oxidative stress, and inflammation in human glomerular mesangial cells