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15 pag.: 286305 C.R

doi: 10.1016/j.cell.2017.09.034 150 MoscatJ.KarinM.Diaz-MecoM

Monti D, Sotgia F, Whitaker-Menezes D, Tuluc M, Birbe R, Berger A, Lazar M, Cotzia P, Draganova-Tacheva R, Lin Z, Domingo-Vidal M, Newberg A, Lisanti MP, Martinez-Outschoorn U

Large-scale CRISPR-based screens have identified thousands of degron motifs, particularly at protein C-termini, regulated by Cullin-RING E3 ligase complexes such as CRL2 and CRL4