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The PRNP promoter contains metal-responsive elements that are targeted by the metal-sensitive transcription factor MTF1, which transactivates PRNP in response to Cu 23

By contrast, during oxidative stress, Nrf2 dissociates from Keap1, translocates to the nucleus, forms a heterodimer with small musculoaponeurotic fibrosarcoma oncogene homolog proteins and binds to ARE, thereby enhancing the transcription of antioxidant genes (6365)

48 week cycles common

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