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doi:10.2289/fimmu.2015.00083

While animal models are by no means a perfect replication of the human disc due to differences in IVD size, cell turnover, and biomechanical load, they have served as important starting points for developmental and degenerative studies as well as preclinical studies for therapeutics

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Although there are studies showing that bFGF improves the biomechanical function of healed tendons, opposite researches have disproved this conclusion ( FIGURE 3 Since growth factors have a short half-life in the body, repeated injections of growth factors are required, which is more time-consuming and laborious, so some delivery vehicle for growth factors is needed to enable their sustained release, such as scaffolds in tissue engineering (Zhao et al., 2014)

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